Molar Volumes And Jone Dole Coefficients Of Dihydropyrimidines And Its Derivatives

Description

'This present book \"Molar Volumes and Jone Dole Coefficients of Dihydropyrimidines and its Derivatives\". The book describes the synthesis and characterization of biologically active dihydropyrimidines and its derivatives. Different parameters such as apparent molar volume, Falkenhagen coefficient, JohnDole coefficient of dihydropyrimidines have been evaluated using density and viscosity measurement in 60 per cent aqueous dimethyl sulphoxide (DMSO) at 313.15 K using different concentration ranging from 0.0002 to 0.01 M using Masson s equation. Such parameters gives identification of molecular interactions in ternary system.'

Table of Contents

Preface v 1. General Review 1 1.1 Introduction 1 1.2 Electromagnetic Radiation and Spectroscopy 2 1.2.1 Ultraviolet (UV) and Visible Spectroscopy 2 1.2.2 IR Spectroscopy (Infrared Spectroscopy) 4 1.2.3 NMR Spectroscopy (Nuclear Magnetic Resonance Spectroscopy) 6 1.4 Solution Chemistry 7 1.5 Density and Viscosity 8 1.6 Present-Day work 9 1.7 References 9 2. Characterization of Synthesized Dihydropyrimidines and its Derivatives 13 2.1 Introduction 13 2.2 Literature Methods for the Synthesis of Substituted Dihydropyrimidine Carbonitriles, Dihydropyrimidine-2(1H)- ones and Dihydropyrimidine Carboxylates 15 viii 2.3 Present Work 18 2.3.1 Synthesis of Dihydropyrimidine Carbonitrile (4a-4e) 18 2.3.2 Synthesis of Dihyropyrimidin-2(1H)-one (5a-5e) 21 2.3.3 Synthesis of Dihydropyrimidine Carboxylates (6a-6e) 24 2.4 Experimental 26 2.4.1 General Procedure for Synthesis of Dihydropyrimidine Carbonitrile 26 2.4.2 General Procedure for Synthesis of Dihyropyrimidin- 2(1H)-one 27 2.4.3 General Procedure for Synthesis of Dihydropyrimidine Carboxylate 28 2.6 IR and 1H NMR Spectrum of Synthesized Deivatives 29 2.5 Conclusion 41 2.7 References 41 3. Method, Purification and Measurement of Density and Viscosity 45 3.1 Introduction of Materials 45 3.2 Purification of Solvents 45 3.2.1 Water 46 3.2.2 Dimethyl Sulphoxide (DMSO) 46 3.3 Measurement of Density and Viscosity 47 3.3.1 Density 47 3.3.2 Calibration Method 47 3.3.3 Density Measurement of Solutions 50 3.3.4 Viscosity 51 3.3.5 Calibration Method 52 3.3.6 Viscosity Measurement of Solutions 54 3.4 Preparation of Solutions 54 3.4.1 Preparation of Aqueous Dimethyl Sulphoxide 54 3.4.2 Preparation of Stock Solution of Dihydropyrimidine and its Derivatives 54 3.5 References 56 4. Densitometric and Viscometric Studies of Dihydropyrimidines and its Derivatives 59 4.1 Introduction 59 4.2 Literature Survey 61 ix 4.3 Present Work 72 4.4 Result and Discussion 73 4.4.1 Density and Viscosity of Dihydropyrimidine Carbonitrile (4a-4e) 73 4.4.2 Density and Viscosity of Dihydropyrimidin-2(1H)- ones (5a-5e) 79 4.4.3 Density, Viscosity of Dihydropyrimidine Carboxylates (6a-6e) 88 4.5 Conclusion 96 4.6 References 97 Index 101 Read more

About the Author/Editor

Dr. Manoj Ramesh Gaware has completed M.Sc. in Organic Chemistry from Savitribai Phule Pune University in 2003 and has been awarded Ph.D. by Savitribai Phule Pune University in 2017. Recently he is working as Associate Professor in Department of Chemistry, Maratha Vidya Prasarak Samaj's G.M.D Arts, B. W. Commerce and Science College, Sinnar. He is Recognised guide by Savitribai Phule Pune University, Pune. He has total 17 years teaching experience. He has published 37 research papers in reputed International Journals indexed in Scopus and Web of Science. He has completed 01 minor research project funded by UGC, New Delhi. He has presented 08 papers at different National and International seminars, conferences and workshops. He has published one International book. He has published a patent on Medicinal Plant leaf extracts that are used to treat plant diseases were put up against each other in a physicochemical test. He has attended various national and international seminars, workshops and conferences. He has been awarded by 01 state and 05 National award in the education field. He has been invited as resource person in different colleges. As a part of community service he has started soil and water testing laboratory in the college. Miss. Ankita Mukund Rayate has completed M.Sc. in Organic Chemistry from Savitribai Phule Pune University in 2018 and has registered for Ph. D. in Savitribai Phule Pune University. Recently she is working as Assistant Professor in Department of Chemistry, Maratha Vidya Prasarak Samaj's G.M.D Arts, B. W. Commerce and Science College, Sinnar. She has total 03 years teaching experience. She has presented papers at National and International seminars, conferences and workshops and has published a paper in International journal. She has published a patent on Medicinal Plant leaf extracts that are used to treat plant diseases were put up against each other in a physicochemical test. She has attended various national and international seminars, workshops and conferences. As a part of community service she has contributed to different activities organized by college. Read more